Grief is an experience that touches everyone at some point, whether it’s the loss of a loved one or something deeply cherished. It’s a personal and complex process that affects us emotionally and physically. Recent neuroscience research has uncovered fascinating insights into how grief changes the brain. By understanding these changes we learn to navigate the challenges of grief with greater skill and compassion.

Brain parts responsible for emotion

Understanding the neuroscience of grief

Our brain, a remarkable organ, regulates our emotions and behaviours. The amygdala, hippocampus, and prefrontal cortex largely influence emotional processing. Scientific studies show that grief significantly affects these regions, leading to emotional regulation and cognitive functioning changes.

For example, during grief, the amygdala becomes hyperactive. This heightened activity makes us more vulnerable to intense emotions, such as sadness, anger, and anxiety. Those grieving often describe it as ‘being on an emotional rollercoaster, where tears flow one moment, and anger flares the next’.

In addition, the hippocampus, responsible for memory formation, undergoes structural changes during prolonged grief. These changes often manifest as intrusive memories, flooding the mind unexpectedly and making it challenging to focus or engage. Take the example of Sarah.


During a crucial team meeting, Sarah’s colleague said, “I don’t see why people get so upset just because their pet dies.” Unbeknown to her colleague, Sarah had euthanised her dog the previous day on the advice of her vet. In that instant, Sarah’s tears welled up, uncontrollable and unexpected. The intense sadness engulfed her, leaving her struggling to participate effectively in the discussion.

But that wasn’t all.

sad lady

As Sarah tried to push through her work, intrusive memories relentlessly flooded her mind. The guilt of ending her dog’s life (despite the vet reassuring her it was the best decision) made it nearly impossible to concentrate on her tasks. The constant battle between her overwhelming feelings of heartbreaking guilt and professional responsibilities left her feeling drained and unable to perform at her best.

Neurotransmitters and the grieving brain

Neurotransmitters, the brain’s messengers, also play a vital role in regulating our moods and emotions. Serotonin, dopamine, and norepinephrine are neurotransmitters closely linked to grief. Studies suggest that individuals experiencing grief often show alterations in these neurotransmitter systems.

grief changes your brain

Take serotonin, often called the “feel-good” neurotransmitter. Decreased serotonin levels have been observed in people with depression and may also contribute to the sadness and low mood experienced during grief.

Similarly, dopamine, responsible for pleasure and reward, can be disrupted in grief. This dysregulation can diminish our ability to experience joy and lead to anhedonia, where activities that once brought pleasure no longer do.

For instance, someone mourning the loss of a partner may find that hobbies or spending time with friends no longer evoke the same joy. This diminished capacity intensifies feelings of emptiness, adding to the overall emotional toll of grief.

Stress response and grief

Grief triggers the body’s stress response, triggering a cascade of physiological reactions. The hypothalamic-pituitary-adrenal (HPA) axis, responsible for releasing stress hormones, plays a significant role in the body’s response to grief. Prolonged grief can dysregulate the HPA axis, resulting in persistently elevated levels of stress hormones like cortisol.

This dysregulation can impact the prefrontal cortex, which governs decision-making and impulse control. Grieving individuals often struggle with choices, from simple daily decisions to significant life-altering ones. Concentration and clear thinking may also be compromised, making practical matters and work-related tasks more challenging.

Neuroplasticity and grief

The brain’s ability to adapt, known as neuroplasticity, plays a vital role in the brain’s response to grief. Research demonstrates that grieving induces structural and functional changes in the brain. Neuroimaging studies have shown alterations in the volume and connectivity of brain regions involved in emotional processing and memory. These changes may underlie the persistent emotional pain and difficulty adapting to life without the deceased.

Resilience and coping mechanisms

While grief has a profound impact on the brain, it’s crucial to acknowledge the innate resilience and coping mechanisms individuals possess. Positive experiences, social support, and engaging in activities promoting wellbeing can facilitate neuroplasticity and aid in recovery.

Psychotherapy, mindfulness practices, and physical exercise have positively affected the brain’s response to grief. Therapy, in particular, provides coping strategies and compassionate support, leading to improved emotional regulation and cognitive functioning. Mindfulness practices and regular exercise release endorphins, promoting neuroplasticity and facilitating the grief recovery journey.


Grief leaves an indelible mark on the brain, triggering an emotional rollercoaster of sadness, anger, and anxiety. Intrusive memories hinder concentration, like in Sarah’s tearful breakdown during a meeting. Depleted serotonin and faltering dopamine intensify depression and steal joy from once-loved activities. The stress response disrupts decision-making and concentration. Yet, hope lies in the brain’s adaptability—neuroplasticity. Therapy restores regulation and function, while mindfulness and exercise release endorphins for healing. Combining neuroscience with compassion unlocks the brain’s potential. Grief is a transformative journey, deeply personal and complex. Remember this when supporting someone through loss; empathy can help them heal and flourish.